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1 临床资料及方法1.1 临床资料 我院于1994年2月～1995年2月间应用大剂量鲁米那治疗34例新生儿缺血缺氧性脑病取得满意疗效。其中对照组,男19例,女13例,日龄<1天者24例,1天～2天者8例,出生5分钟Apgar评分0～3分7例,4～7天者28例,1天～2天者6例,出生5分钟 Apgar评分0～3分5例, 4～7分29例,两组患儿均符合1989年济南会议“新生儿缺血缺氧性脑病诊断标准”。两组患儿临床表现及CT检查经统计学处理,无显著差异,详见表1。 表1 两组患儿临床表现及CT检查对比1.2 治疗方法 治疗组:在对照组常规抗炎、降颅压、止痉、吸氧等对症治疗基础上佐以大剂量鲁米那,首次15～20mg/kg静推,以后改为3～5mg/kg每日维持,总疗程5天。1.3 结果 疗效判定标准:临床症状及脑水
1 Clinical data and methods 1.1 Clinical data in our hospital in February 1994 ~ February 1995 application of high-dose luminal therapy of 34 cases of neonatal hypoxic-ischemic encephalopathy achieved satisfactory results. The control group, 19 males and 13 females, day <1 day in 24 cases, 1 day to 2 days in 8 cases, 5 minutes of birth Apgar score 0 to 3 in 7 cases, 4 to 7 days in 28 cases, 1 day to 2 days in 6 cases, 5 minutes of birth Apgar score 0 to 3 in 5 cases, 4 to 7 in 29 cases, both groups of children are in line with the 1989 Jinan meeting “neonatal hypoxic-ischemic encephalopathy diagnostic criteria” . Two groups of children with clinical manifestations and CT examination by statistical analysis, no significant differences, as shown in Table 1. Table 1 Comparison of two groups of children with clinical manifestations and CT examination 1.2 Treatment group: In the control group conventional anti-inflammatory, intracranial pressure, Zhijing, oxygen and other symptomatic treatment based on high dose of luminal, accompanied by the first 15 ~ 20mg / kg static push, later changed to 3 ~ 5mg / kg daily maintenance, the total course of 5 days. 1.3 Results of the efficacy criteria: clinical symptoms and brain water