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一、前言 GC除对挥发性和热不稳的化合物分离条件较易选择外,另一特点是高灵敏度检测器包括选择性检测器的种类较多,熔融硅交联或化学键合毛细管柱的出现,也比过去的玻璃管柱具有非活性、耐久性、耐热性(350℃)等许多优点,可使有些化合物在玻璃毛细管柱上产生的吸附或拖尾等影响减到最小。生物体液中的微量药物的分析要突破两个难关,其一是选择回收率高的提取分离方法,其二是选择灵敏度高的检测方法。本文
I. INTRODUCTION In addition to the ease of separation of volatile and thermally unstable compounds in GC, another feature is the presence of high sensitivity detectors including selective detectors, the presence of fused silica cross-linked or chemically bonded capillary columns. It also has many advantages such as inactivation, durability, heat resistance (350°C), etc., compared to previous glass columns, which can minimize the effects of adsorption or tailing of some compounds on glass capillary columns. The analysis of micro-drugs in biological fluids has to overcome two difficulties. One is to select extraction and separation methods with high recovery, and the other is to select high-sensitivity detection methods. This article