Foam materials have many attractive properties because of their low-weight and cell structure. By sandwiches with an aluminum-foam core, it is possible to obtain higher structural stiffness and rigidity, maintain stability against buckling and additionally make use of the high energy dissipation capability of the bare foams. The most obvious and straightforward one is adhesive bonding of pre-fabricated aluminum foams and metal face sheets. A new manufacture processing is proposed for preparation of aluminum alloy foam sandwich, ie., Al-plate/mixed element powder/ Al-plate are sandwich rolled together by a large reduction in pass, which is then foamed in heating furnace to manufacture end-use product. Aluminum alloy foam sandwich is obtained in this experiment. The experimental results showed that the process of rolling interface belongs to mechanical bonding, whose mechanism is film theory. While interface bonding belong to metallurgy bonding in the process of foaming, Al atom interdiffused in the interface, and no new phase was generated in the foaming process of aluminum face sheet/powders precursor. Bending fatigue test results showed that the bonding force of the foamed sandwich interface is very high, in fatigue test fracture occurred in the whole foam aluminum sandwich panels and Al/foam core interface was not laminated.