脂肪细胞脂肪酸结合蛋白(FABP4)是脂肪酸结合蛋白家族的成员,与饱和/不饱和长链脂肪酸、类花生四烯酸和其他脂质有高度亲和力,参与脂肪酸的吸收、转运和代谢,在糖脂代谢、炎症反应中起重要作用。新近研究发现,FABP4在代谢综合征、心血管疾病、糖尿病等疾病中发挥重要作用,并与妊娠相关疾病,如子痫前期、妊娠期糖尿病发病相关。明确其作用机制及影响因素,可为相关疾病预防和治疗提供新思路。 Adipocyte fatty acid-binding protein (FABP4), a member of the fatty acid binding protein family, has high affinity for saturated / unsaturated long chain fatty acids, arachidonic acid and other lipids, is involved in the absorption, transport and metabolism of fatty acids, Metabolism, inflammation plays an important role. Recent studies have found that FABP4 plays an important role in diseases such as metabolic syndrome, cardiovascular diseases and diabetes and is associated with pregnancy-related diseases such as preeclampsia and gestational diabetes. To clarify its mechanism of action and its influencing factors can provide new ideas for the prevention and treatment of related diseases.