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报道绞股蓝多糖（ＧＰＳ）对小鼠肉瘤Ｓ－１８０和Ｅｃａ－１０９细胞的抑制作用。结果表明：①用浓度为１０ｇ／Ｌ的ＧＰＳ对荷瘤小鼠每１２ｈ灌胃１次，每次０．５ｍｌ，连续１０ｄ后测得对Ｓ－１８０肉瘤的抑制率为８．５％，与生理盐水对照组无显著性差异（Ｐ＞０．０５）；用浓度为２０ｇ／Ｌ的ＧＰＳ用同样方法测得对肉瘤Ｓ－１８０的抑制率为３１％，与生理盐水对照组有显著性差异（Ｐ＜０．０５）。②ＧＰＳ用于体外培养的人食管癌细胞ＥＣａ－１０９随药物浓度增大和时间延长对ＥＣａ－１０９细胞株的抑制率呈正相关，ＧＰＳ的浓度为１ｇ／Ｌ时，７２ｈ的抑制率为１００％；ＧＰＳ的浓度为２ｇ／Ｌ时，４８ｈ的抑制率为１００％。提示：ＧＰＳ对肿瘤细胞有较强的抑制和杀伤作用。
The inhibitory effect of Gynostemma pentaphyllum polysaccharide (GPS) on mouse sarcoma S-180 and Eca-109 cells was reported. The results showed that: 1 with a concentration of 10g / L of GPS on tumor-bearing mice every other 12h intragastric administration, 0.5ml each, after 10d continuous measurement of S-180 sarcoma inhibition rate was 8.5%, and There was no significant difference in the normal saline control group (P>0.05); the inhibition rate of sarcoma S-180 was measured by the same method with a GPS concentration of 20 g/L, which was significantly different from that of the normal saline control group. (P<0.05). 2GPS used in vitro cultured human esophageal cancer cells ECa-109 with the increase in drug concentration and time prolonged inhibition of ECa-109 cell lines was positively correlated, GPS concentration of 1g / L, 72h inhibition rate was 100%; GPS When the concentration was 2 g/L, the inhibition rate at 48 h was 100%. Tip: GPS has a strong inhibition and killing effect on tumor cells.