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目的 通过检测血清透明质酸（ＨＡ） 、Ⅲ型前胶原（ＰＣⅢ） 、Ⅳ型胶原（ＣⅣ） 及层粘素（ＬＮ） 的水平，了解该四项血清指标与肝纤维化及早期肝硬化的关系。方法 ３６ 例慢性乙型肝炎（ 慢乙肝） 患者的血清ＨＡ、ＰＣⅢ及ＬＮ 用放免法检测（ ＲＩＡ） ；ＣⅣ用酶免法检测（ＥＩＡ） ，并与肝穿病理炎症分级（Ｇ） 和纤维化分期（Ｓ） 进行比较。结果 血清中ＨＡ、ＰＣⅢ、ＣⅣ及ＬＮ 水平与肝纤维化及早期肝硬化关系密切（ Ｐ＜ ０－０５ － ０－０１） 。结论 血清中ＨＡ、ＰＣⅢ、ＣⅣ及ＬＮ 均为较好反映肝纤维化及早期肝硬化的指标。其中ＨＡ 价值最大，ＰＣⅢ对肝脏炎症反映较好
Objective To detect the levels of serum hyaluronic acid (HA), type Ⅲ procollagen (PC Ⅲ), type Ⅳ collagen (C Ⅳ) and laminin (LN) in serum and liver fibrosis and early liver cirrhosis relationship. Methods Serum HA, PC Ⅲ and LN were detected by radioimmunoassay (RIA) in 36 patients with chronic hepatitis B (CHB). CⅣ was detected by enzyme immunoassay (EIA) Stages (S) for comparison. Results Serum levels of HA, PCⅢ, CⅣ and LN were closely related to liver fibrosis and early liver cirrhosis (P <0-05-0-01). Conclusion Serum HA, PCⅢ, CⅣ and LN are indicators of liver fibrosis and early cirrhosis. Among them, HA is the most valuable and PCⅢ reflects the inflammation of the liver better