作者对30例肺癌患者,26例吸烟者及25例非吸烟者的外周血和支气管肺泡灌洗液(BALF)中的T淋巴细胞亚群(T-LS)进行了测定.结果显示:外周血T-LS变化不大;BALF中CD_3％三组间无明显差异,但CD_4％、CD_4/CD_3比值肺癌患者<吸烟者<非吸烟者,而CD_3％则肺癌患者>吸烟者>非吸烟者.提示肺癌患者与吸烟者肺局部细胞免疫功能均有减退,其程度以肺癌患者为重。吸烟所致的肺局部T-LS的改变可诱发肺癌,而肺癌发展过程中又可加重免疫抑制,促进肿瘤生长,两者互为因果。 The authors measured the T-lymphocyte subsets (T-LS) in peripheral blood and bronchoalveolar lavage fluid (BALF) in 30 lung cancer patients, 26 smokers and 25 non-smokers. The results showed that: T-LS did not change much; CD3% in BALF had no significant difference among the three groups, but CD_4%, CD_4/CD_3 ratio lung cancer patients smokers> non-smokers. It suggests that the cellular immune function of the lungs of lung cancer patients and smokers are both decreased, and the degree of lung immunity is the most important. The change of lung T-LS caused by smoking can induce lung cancer, while the development of lung cancer can aggravate the immunosuppression and promote tumor growth, and the two are mutual cause and effect.