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抗菌化学治疗时补体和其他的体液因素,还有嗜中性细胞和巨噬细胞等细胞免疫等作特异性防御系统,在细菌感染中可能对致病菌起协同杀菌作用。有些研究证明,在抗体存在时培养革蓝氏阴性杆菌,看到细菌外膜受到伤害,起免疫杀菌作用。β-内酰胺类抗生素主要作用于细菌的细胞壁,抑制其合成而达到杀菌作用。由此,补体和抗生素的协同作用值得探讨。研究用体外培养方法,以补体同11个噻吩类β-内酰胺抗生素对三类细菌的相互作用,阐明作用关系。在补体存在时,噻吩类抗生素对大肠杆菌(NIHJ JC-2),绿脓杆
Antibacterial chemical treatment of complement and other humoral factors, as well as neutrophils and macrophages and other cellular immunity for specific defensive system, bacterial infection may act synergistically bactericidal pathogenic bacteria. Some studies have shown that the culture of Gram-negative bacilli in the presence of antibodies, bacterial outer membrane damage, immune bactericidal effect. β-lactam antibiotics mainly act on the cell wall of bacteria to inhibit their synthesis and achieve bactericidal effect. Thus, the synergy of complement and antibiotics worth exploring. Study with in vitro culture method to complement with 11 thiophene β-lactam antibiotics on the interaction of the three types of bacteria to clarify the role of relations. In the presence of complement, thiophene antibiotics against E. coli (NIHJ JC-2), Pseudomonas aeruginosa