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目的探讨Creutzfeldt-Jakob病(Creutzfeldt-Jakob disease,CJD)临床特点及神经影像学表现。资料与方法回顾性分析和总结2例CJD病患者的临床表现及影像学特点、脑电图改变等资料,并复习文献。结果 2例患者均表现为基底核及多部位的灰质皮层扩散加权成像(DWI)高信号,T1WI未见异常信号,T2WI和液体衰减反转恢复序列(FLAIR)呈稍高信号,脑电图异常及脑脊液14-3-3蛋白阳性。结论 DWI显示皮层灰质和(或)纹状体信号增高,对CJD的早期诊断具有高度的敏感性。在具有相关临床症状而常规MRI不能解释的脑部检查中,DWI检查可能会发现异常信号。
Objective To investigate the clinical features and neuroimaging findings of Creutzfeldt-Jakob disease (CJD). Materials and Methods Retrospective analysis and summary of 2 cases of CJD patients with clinical manifestations and imaging features, EEG changes and other data, and review the literature. Results High DWI signals were found in both basilar and multi-site gray matter in both of the two groups. There was no abnormal signal in T1WI, slightly higher signal in T2WI and FLAIR, and abnormal EEG And CSF protein 14-3-3 positive. Conclusions DWI shows that the signal of gray matter and / or striatum in cortex is increased, which is highly sensitive to the early diagnosis of CJD. In brain exams with related clinical symptoms that conventional MRI can not interpret, DWI may detect abnormal signals.