将昆虫生长调节剂灭幼脲的活性基团和蜕皮激素模拟物 RH- 584 9和 RH- 5992的活性基团进行拼接 ,合成了十二个全新的 2 -叔丁基 - 1-芳酰基 - 4 -芳基氨基脲类目标化合物 ,其结构经 IR,1H NMR,MS和元素分析确证。生物测试结果表明 ,该系列化合物有一定的昆虫生长调节活性。通过 QSAR分析 ,找出了该系列化合物的结构 -活性定量方程 ,并进行了统计学和化学的检验。也为今后继续优化该系列化合物提供理论依据。 The active groups of the insect growth regulator diflubenzuron and the active groups of ecdysone mimics RH- 584 9 and RH- 5992 were spliced ​​to synthesize twelve new 2-tert-butyl-1-aroyl- The target compounds of 4 - arylsemicarbazides were confirmed by IR, 1H NMR, MS and elemental analysis. Biological test results show that the series of compounds have certain insect growth regulatory activity. Through the QSAR analysis, the structure-activity quantitative equations of this series of compounds were found, and the statistical and chemical tests were carried out. But also provide a theoretical basis for further optimization of the series of compounds in the future.