目的探讨PET在癫痫术前定位中的应用。方法 4例难治性癫痫患者术前进行长程视频脑电图,MRI及PET检查。结果经PET定位后行手术治疗患者,随访1～3年,癫痫控制效果满意。结论 PET对于颞叶癫痫的诊断与定位具有非常高的准确性。在发作间期进行PET检查时,如果检查结果与脑电不符时应慎重进行判定,尽可能确定有无临床下发作的可能。 Objective To investigate the application of PET in preoperative localization of epilepsy. Methods Four patients with refractory epilepsy were examined by long-range video EEG, MRI and PET before operation. Results The patients underwent PET after location and operation were followed up for 1 to 3 years and the effect of epilepsy control was satisfactory. Conclusion PET has a very high accuracy in the diagnosis and localization of temporal lobe epilepsy. During the PET examination during the attack, if the test results do not match with the EEG should be judged carefully, as far as possible to determine whether the possibility of clinical attack.