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[目的]观察痛泻要方水提浸膏及其萃取后母液部分的药效学,探索该复方的有效部位或成分。[方法]采用大鼠体外肠肌的振幅和基线变化为观察指标,比较痛泻要方水提浸膏及其萃取成分对大鼠体外肠肌的影响。[结果]痛泻要方水提浸膏能明显抑制大鼠小肠上、中、下段和结肠段体外肠肌的振幅和基线(P<0.05);浸膏经萃取分离后的母液部分仅对大鼠体外小肠中段振幅抑制有统计学意义(P<0.05)。[结论]痛泻要方水提浸膏能够抑制大鼠体外肠管肌运动的振幅和基线,经萃取分离得到的母液部分不能达到与原复方相同的效果。
[Objective] To observe the pharmacodynamics of Tongxie Yaofang extract and its mother liquor after extraction and explore the effective part or composition of the compound. [Methods] The changes of the amplitude and baseline of rat intestine muscle in vitro were used as observation indexes to compare the effects of Tongxie Yaofang extract and extract components on rat intestinal muscle in vitro. [Results] The Tongxie Yaofang Shuiti extract could obviously inhibit the amplitude and baseline of the intestine muscle of the upper, middle and lower segments of the small intestine of the rat (P<0.05). The mother liquor of the extract after the extraction and separation was only large. The amplitude of inhibition in the middle small intestine of mice was statistically significant (P<0.05). [Conclusion] Tongxie Yaofang Shuiti extract can inhibit the amplitude and baseline of rat intestine muscle movement in vitro. The mother liquor extracted and separated can not achieve the same effect as the original compound prescription.