论文部分内容阅读
目的了解杭州市下城区早期发现艾滋病病毒(HIV)感染者状况及其影响因素,为开展艾滋病早期发现、早期治疗提供参考依据。方法 2009—2013年对辖区新发现HIV感染者开展随访,定期检测CD+4T淋巴细胞,分析从抗体确认到首次CD+4T淋巴细胞检测时间间隔,以及首次CD+4T淋巴细胞数值变化趋势,并采用单因素和多因素logistic回归的方法分析人口学特征、检测机构、样本来源和接触史等因素对早期发现HIV感染者的影响。结果 2009—2013年辖区共新发现HIV感染者738例,已检测CD+4T淋巴细胞663例,占89.8%,其中从抗体确认到首次检测CD+4T淋巴细胞时间间隔<1个月占58.4%,≥1个月占27.9%,≥3个月占11.6%,≥1年占2.1%。各年份CD+4T淋巴细胞数值较低的构成比差异无统计学意义(P>0.05)。年龄、婚姻、户籍、文化程度、检测机构、接触史和样本来源是早期发现HIV感染者的影响因素,差异有统计学意义(P<0.05);检测已婚有配偶者、离异或丧偶者以及通过其他就诊者检测、术前检测和阳性者配偶或性伴检测不容易早期发现HIV感染者,其比值比分别为0.494(95%CI:0.286~0.853)、0.609(95%CI:0.374~0.994)、0.251(95%CI:0.143~0.440)、0.346(95%CI:0.177~0.675)、0.318(95%CI:0.109~0.928)。结论杭州市下城区早期发现HIV感染者的能力基本稳定;加强对未婚者的检测咨询,有利于早期发现HIV感染者。
Objective To understand the status of early detection of HIV infection in lower city of Hangzhou and its influencing factors, and provide reference for early detection and early treatment of AIDS. Methods From 2009 to 2013, follow-up was conducted on newly discovered HIV-infected patients in our area. CD + 4T lymphocytes were detected regularly. The interval from the first antibody confirmation to the first CD + 4T lymphocyte assay and the trend of the first CD + 4T lymphocyte numbers were analyzed. Univariate and multivariate logistic regression analysis of demographic characteristics, testing institutions, sample sources and exposure history and other factors on the early detection of HIV infection. Results A total of 738 HIV-infected patients were found in the area from 2009 to 2013. 663 CD + 4T lymphocytes were detected, accounting for 89.8% of the total. Among them, the interval from first antibody detection to CD + 4T lymphocyte count was 58.4% , ≥1 month accounted for 27.9%, ≥3 months accounted for 11.6%, ≥1 year accounted for 2.1%. There were no significant differences in the constituent ratios of CD + 4T lymphocytes in all years (P> 0.05). Age, marital status, household registration, educational level, testing organization, exposure history and sample source were the influencing factors of early detection of HIV infection (P <0.05); the detection of married spouse, divorced or widowed, and The odds ratios were 0.494 (95% CI: 0.286-0.853), 0.609 (95% CI: 0.374-0.994), and the prevalence of HIV infection was significantly higher in HIV-infected subjects than in other HIV-positive controls ), 0.251 (95% CI: 0.143-0.440), 0.346 (95% CI: 0.177-0.675) and 0.318 (95% CI: 0.109-0.928). Conclusion The ability of early detection of HIV-infected persons in Xiacheng District of Hangzhou was basically stable. Strengthening the testing and counseling of unmarried people was beneficial to early detection of HIV-infected persons.