肿瘤的发生与发展是多基因参与、多因素作用的复杂过程,是环境因素和遗传因素相互作用的结果。遗传因素是个体对肿瘤发生易感性的内因。肿瘤不仅是细胞增殖与分化异常的疾病,也是细胞凋亡异常的疾病。Fas及其配体FasL是凋亡相关基因,Fas/FasL系统的功能紊乱是肿瘤细胞逃避机体 The occurrence and development of tumors is a complex process of multi-gene participation and multi-factorial effects, and is the result of the interaction between environmental factors and genetic factors. Genetic factors are the internal cause of an individual’s susceptibility to tumorigenesis. Tumor is not only a cell proliferation and differentiation disorders, but also a disease of abnormal apoptosis. Fas and its ligand FasL are apoptosis-related genes. The functional disorder of Fas / FasL system is that tumor cells escape from the body