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质子泵抑制剂(PPI)被用于幽门螺杆菌(Hp)的治疗是因为此类药物对抗生素作用于微生物有极大影响。在胃内胃酸能够降解抗生素,而用于治疗Hp的抗生素对酸的敏感性不同。甲硝唑(Metronidazole)在pH2和pH7的胃酸中非常稳定,其半衰期超过800h。阿莫西林(Amoxicillin)虽然在低pH胃酸中
Proton pump inhibitors (PPIs) are used in the treatment of Helicobacter pylori (Hp) because these drugs have a dramatic effect on the action of the antibiotic on the microorganisms. Acid in the stomach can degrade antibiotics, and antibiotics used to treat Hp have different acid sensitivity. Metronidazole is very stable in gastric acid at pH 2 and pH 7 with a half-life of over 800 h. Amoxicillin is in low pH gastric acid