性早熟是儿科内分泌系统的常见发育异常,为了规范中枢性(真性)性早熟的诊断和治疗,中华医学会儿科学分会内分泌遗传代谢学组进行了专题讨论,制定以下指南供临床参考。[定义]性早熟是指女童在8岁前,男童在9岁前呈现第二性征的发育异常性疾病。中枢性性早熟(CPP)是缘于下丘脑提前增加了促性腺激素释放激素(GnRH)的分泌和释放量,提前激活性腺轴功能,导致性腺发育和分泌性激素,使内、外生 Precocious puberty is a common developmental abnormality of pediatric endocrine system. In order to standardize the diagnosis and treatment of central (true) precocious puberty, the Chinese Academy of Pediatrics Pediatric Endocrinology Metabolism Group conducted a special discussion and made the following guidelines for clinical reference. [Definition] Precocious puberty refers to the developmental abnormalities in which girls have secondary sexual characteristics before age 9 before the age of 8. Central precocious puberty (CPP) is due to the hypothalamus early increase in gonadotropin-releasing hormone (GnRH) secretion and release, in advance activation of gonadal axis function, leading to gonadal development and secretion of hormones, so that the exogenous