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目的探讨应用液基细胞学(TCT)检测方法筛查早期子宫颈癌及癌前病变的临床应用价值。方法对2007年1月至2010年9月在西平县妇幼保健院妇科门诊就诊、妇女进行宫颈TCT检查,诊断报告应用TBS分级标准,对细胞学诊断为ASC-UC以上者行阴道镜检查及活检。结果2 236例TCT检测结果中,异常者176例,检出率7.87%,其中不典型鳞状上皮细胞(ASC-US)133例(5.95%),不典型腺上皮细胞(AGC-US)2例(0.09%),低度鳞状上皮内病变(LSIL)10例(0.44%),高度鳞状上皮内病变(HSIL)24例(1.07%),鳞状细胞癌(SCC)7例(0.31%)。对176例阳性者行阴道镜下活检,检出宫颈鳞癌8例,CINⅢ16例,CINⅡ15例,CINⅠ19例,炎症118例。结论 TCT技术应用于宫颈病变的筛查,可明显提高标本的满意度,配合阴道镜下多点活组织病理检查,能极大提高宫颈癌前病变及宫颈癌的检出率,是宫颈病变筛查的有效方法。
Objective To investigate the clinical application of liquid-based cytology (TCT) screening for early cervical cancer and precancerous lesions. Methods From January 2007 to September 2010, gynecological clinic of Xiping Maternal and Child Health Hospital was conducted. Women had cervical TCT examination. TBS grade was used in the diagnosis report. Colposcopy and biopsy were performed on the cytologically diagnosed as ASC-UC . Results A total of 176 samples were detected by TCT in 2 236 cases, with a detection rate of 7.87%. Among them, 133 cases (5.95%) of atypical squamous epithelial cells (ASC-US), 9 cases of atypical glandular epithelial cells 10 cases (0.44%) had low grade squamous intraepithelial lesion (LSIL), 24 cases (1.07%) had high grade squamous intraepithelial lesion (HSIL), 7 cases had squamous cell carcinoma (SCC) %). 176 cases of positive colposcopy biopsy, detected in 8 cases of cervical squamous cell carcinoma, CIN Ⅲ in 16 cases, CIN Ⅱ in 15 cases, CIN Ⅰ in 19 cases, inflammation in 118 cases. Conclusion The TCT technique can be applied to the screening of cervical lesions, which can significantly improve the satisfaction of specimens. Combined with colposcopic multi-point biopsy, TCT can greatly improve the detection rate of cervical precancerous lesions and cervical cancer. Check the effective method.