As a physical stimulation of the body surface,the process of transmitting acupuncture information from acupoints to target organs through meridians and collaterals is complex,and network regulation is the most basic mode of acupuncture.Exosomes are membrane vesicles formed by various types of cells and secreted to the extracellular matrix through a series of regulation.We speculate that exosomes and their carriers,as important carriers of communication among neurons,endocrine cells,and immune cells,may play an important role in the process of acupuncture information transmission.Exosome in the acupoint area is an important interactive form of transformation from physical information to chemical information.Circulating exosome is an important means of delivery for acupuncture to play an important role in the network regulation.The structure and information molecules of exosomes are the important material bases for acupuncture effect.Through experimental research,it was found that acupuncture can regulate the release of exosome and may have a certain relationship with acupuncture effect.Therefore,exosome may play an important role in the process of acupuncture information transmission,which is an important new way of acupuncture information transmission.