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目的探讨2型糖尿病患者尿山梨醇与周围神经病变(DPN)的关系。方法采用固相夹心酶联免疫吸附法测定63例2型糖尿病患者(无DPN组),134例2型糖尿病周围神经病变患者(DPN组)和72例正常对照组的24 h尿山梨醇排泄量,并分析其与病程、血糖、糖化血红蛋白、血清胰岛素、甘油三酯、总胆固醇、尿白蛋白排泄率(UAER)和神经传导速度的关系。结果2型糖尿病DPN患者尿山梨醇水平高于无DPN组和正常对照组(P<0.05或<0.01);2型糖尿病患者尿山梨醇水平与神经传导速度呈负相关,与病程和UAER(P<0.05或<0.01)呈正相关。结论尿山梨醇可作为2型糖尿病周围神经病变的检测指标。
Objective To investigate the relationship between urinary sorbitol and peripheral neuropathy (DPN) in type 2 diabetic patients. Methods The urinary sorbitol excretion of 63 patients with type 2 diabetes mellitus (without DPN group), 134 type 2 diabetic peripheral neuropathy patients (DPN group) and 72 normal controls were measured by solid-phase sandwich enzyme-linked immunosorbent assay , And analyzed its relationship with the course of disease, blood glucose, glycosylated hemoglobin, serum insulin, triglyceride, total cholesterol, urinary albumin excretion rate (UAER) and nerve conduction velocity. Results The level of urinary sorbitol in DPN patients with type 2 diabetes mellitus was higher than those without DPN and normal controls (P <0.05 or <0.01). Urinary sorbitol levels in type 2 diabetic patients were negatively correlated with nerve conduction velocity, <0.05 or <0.01). Conclusion Urinary sorbitol can be used as a marker of type 2 diabetic peripheral neuropathy.