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严重细菌感染和脓毒症是目前重症监护室(ICU)发病率和病死率高的主要原因~([1])。对其早期识别和进行临床干预才有望提高脓毒症患者的预后。细菌感染的患者临床症状和体征无特异性,根据血常规、胸部影像学或者微生物检测不能确定感染的真实情况。现有的许多微生物学检测方法主要不足之处在于诊断的延迟性(例如培养方法 )、不理想的敏感性(例如血培养)以及因污染导致较低的特异性(例如痰培养),而其他一些检测方法因有创性而不能作为临床常规使
Severe bacterial infections and sepsis are the major causes of morbidity and mortality in intensive care units (ICU) [1]. Its early identification and clinical intervention is expected to improve the prognosis of patients with sepsis. Clinical signs and symptoms are not specific in patients with bacterial infections and the true nature of the infection can not be determined by blood tests, chest radiographs or microbiological tests. Many of the existing microbiological detection methods are mainly deficient in diagnostic delay (eg culture method), undesired sensitivity (eg blood culture) and lower specificity due to contamination (eg sputum culture), while others Some testing methods can not be used as clinical routine because of their invasiveness