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氧哌嗪青霉素为一新的广谱半合成青霉素。本文报告其抗菌作用,临床药理和临床应用研究结果。 临床分离的387株细菌药敏测定结果显示本品对革兰氏阳性菌和革兰氏阴性菌均有良好抗菌作用,尤以对革兰氏阴性杆菌的作用为著,其抗菌活性高于呋苄青霉素和氨苄青霉素,而较庆大霉素略差。对绿脓杆菌、变形杆菌、沙门氏菌的抑菌率均在90％左右,对大肠杆菌为79％。 给7名健康志愿者肌注、静注和静滴本品1g后,高峰血浓度分别为25、142.1和58μg/ml。血药浓度进行药物动力学参数计算,肌注为单室开放模型,静注及静滴符合二室开放模型。根据以上参数拟订了对各种感染的不同的给药方案。 氧哌嗪青霉素用于治疗各种感染148例,包括腹膜炎、肺部感染、败血症等严重感染,总有效率为77.7％,治愈率55.4％。临床应用中不良反应少见,对肾、肝、骨髓未见有明显毒性。
Piperacillin is a new broad spectrum semi-synthetic penicillin. This article reports its antibacterial effect, clinical pharmacology and clinical application research results. The clinical isolates of 387 strains of bacteria susceptibility test results show that the product of Gram-positive bacteria and Gram-negative bacteria have good antibacterial effect, especially for Gram-negative bacilli for the role of antibacterial activity higher than the fur Benzyl penicillin and ampicillin, and slightly worse than gentamicin. Bacteriostasis rate of Pseudomonas aeruginosa, Proteus, Salmonella were about 90%, Escherichia coli 79%. Seven healthy volunteers intramuscular injection, intravenous and intravenous infusion of 1g, the peak blood concentrations were 25,142.1 and 58μg / ml. Pharmacokinetic parameters of plasma concentration were calculated. Intramuscular injection was single-chamber open model. Both intravenous and intravenous infusion were consistent with two-compartment open model. Based on the above parameters, different dosing regimens for various infections were developed. Piperacillin is used to treat 148 cases of various infections, including peritonitis, pulmonary infection, sepsis and other serious infections, with a total effective rate of 77.7% and a cure rate of 55.4%. Adverse reactions in clinical applications rare, no obvious toxicity on the kidney, liver, bone marrow.