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目的 对血清中幽门螺杆菌 (Hp)热休克蛋白 (HSP)B抗体 (IgG)的滴度与胃黏膜病理变化之间的关系进行研究 ,以探讨HSPB抗体在Hp相关性疾病中的作用。 方法 从山东胃癌高发区随机取样 10 36例 ,其中Hp阳性者 6 0 0例 ,选取 30 0例行Hp三联根治治疗。第 5年复查胃镜并留血标本 ,随机抽取诊断为Hp阴性慢性浅表性胃炎 ,Hp阳性慢性浅表性胃炎、慢性萎缩性胃炎、消化性溃疡各 2 0例 ,用Westernblot法对患者血中Hp的HSPB抗体滴度进行比较。 结果 Hp阳性慢性浅表性胃炎患者的抗体滴度 (0 .5 0 5± 0 .0 6 1)高于Hp阳性萎缩性胃炎 (0 .4 4 8± 0 .10 5 ,P <0 .0 5 )及消化性溃疡(0 .4 4 7± 0 .10 9,P <0 .0 5 ) ,Hp阴性慢性浅表性胃炎的HSP抗体滴度最低。结论 血清中的HpHSPB抗体对于胃黏膜炎症的加重可能具有一定的保护作用
OBJECTIVE: To investigate the relationship between the titer of anti-Helicobacter pylori (Hp) antibody (IgG) in serum and the pathological changes of gastric mucosa in order to investigate the role of HSPB in Hp-related diseases. Methods A total of 1036 cases were randomly selected from high incidence of gastric cancer in Shandong Province. Among them, Hp was positive in 600 cases and 30 cases were treated with Hp triple therapy. In the 5th year, gastroscope and blood samples were reviewed, and 20 cases of Hp-negative chronic superficial gastritis, Hp-positive chronic superficial gastritis, chronic atrophic gastritis and peptic ulcer were randomly selected. Blood samples were collected by Western blot Hp HSPB antibody titers were compared. Results The antibody titers in patients with Hp-positive chronic superficial gastritis were significantly higher than those in Hp-positive atrophic gastritis (0. 44 ± 0. 105, P <0. 0 5) and peptic ulcer (0.447 ± 0.109, P <0.05), HSP antibody titer of Hp-negative chronic superficial gastritis was the lowest. Conclusions HpHSPB antibody in serum may have a protective effect on the inflammation of gastric mucosa