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目的探讨采用米非司酮保守治疗异位妊娠的临床效果及应用价值。方法回顾性分析100例异位妊娠患者的临床资料,按照随机、对照原则分为对照组和观察组,疗程均为3 d,在普通消炎、止血的基础上,对照组肌肉注射氨甲蝶呤进行治疗,观察组口服米非司酮片,2次/d。观察两组患者症状、体征、包块、腹腔积液的变化情况,比较两组临床治疗效果及不良反应。结果观察组临床效果总有效率为98.0%,对照组临床效果总有效率为84.0%,观察组明显高于对照组,差异有统计学意义(P<0.05);比较两组不良反应,观察组没有不良反应发生,对照组7例发生不良反应,差异有统计学意义(P<0.05)。结论临床采用米非司酮保守治疗异位妊娠起效快且效果显著,且无明显不良反应,能够明显改善患者病情和预后,值得临床进一步推广应用。
Objective To investigate the clinical effect and application value of conservative treatment of ectopic pregnancy with mifepristone. Methods The clinical data of 100 patients with ectopic pregnancy were retrospectively analyzed. According to the principle of randomization and control, the patients were divided into the control group and the observation group. The course of treatment was 3 days. On the basis of common anti-inflammatory and hemostatic effects, the control group received intramuscular methotrexate For treatment, the observation group oral mifepristone tablets, 2 times / d. The changes of symptoms, signs, masses and peritoneal effusion in the two groups were observed. The clinical effects and adverse reactions in both groups were compared. Results The total effective rate was 98.0% in the observation group and 84.0% in the control group. The observation group was significantly higher than that of the control group (P <0.05). The adverse reaction of the two groups was compared with that of the observation group No adverse reactions occurred in the control group, 7 patients had adverse reactions, the difference was statistically significant (P <0.05). Conclusions The clinical use of mifepristone conservative treatment of ectopic pregnancy with rapid onset and significant effect, and no significant adverse reactions, can significantly improve the patient’s condition and prognosis, it is worth further clinical application.