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目的了解全聋型和严重平坦型突发性聋的治疗效果及影响预后的因素。方法对2003年1月至2006年10月就诊的62例听力损失为中重度以上(0.25、0.5、1、2、4 kHz 的平均纯音听阈≥56dB 的突发性聋患者进行研究。其中18例单独应用血栓通(三七总皂苷)治疗,19例应用泼尼松加血栓通治疗,25例应用甲泼尼龙加东菱迪芙加血栓通治疗。结果单独应用血栓通的有效率为22.2%(4/18),显效率为5.6%(1/18),应用泼尼松加血栓通的有效率为57.9%(11/19),显效率为36.8%(7/19),联合应用甲泼尼龙、东菱迪芙、血栓通的有效率为68.0%(17/25),显效率为60.0%(15/25)。经统计学处理,应用皮质类固醇激素加血栓通和或加东菱迪芙治疗中重度以上的平坦型或全聋患者的疗效要明显好于单独应用血栓通(P<0.05)。全聋患者伴眩晕的比率[88.2%(15/17)]明显高于严重平坦型患者[26.7%(12/45)],且疗效较差。结论严重平坦型预后较好,以大剂量皮质类固醇激素和东菱迪芙为主的联合治疗的效果较好;全聋型往往伴有眩晕,预后较差。
Objective To understand the therapeutic effect of all deaf and severe flat sudden deafness and the factors that affect the prognosis. Methods Sixty-two patients with moderate to severe hearing loss (0.25, 0.5, 1, 2, 4 kHz) with mean pure tone hearing threshold ≥56 dB were studied from January 2003 to October 2006. Among them, 18 Thrombus alone (total saponins of Panax notoginseng) treatment, 19 cases of prednisone plus thrombosis treatment, 25 cases of methylprednisolone plus Tailingdi Fucao thrombosis treatment.Results The effective rate of thrombus alone was 22.2% (4/18), the effective rate was 5.6% (1/18). The effective rate of applying prednisone and thrombus was 57.9% (11/19) and the effective rate was 36.8% (7/19) Prednisolone, Donglingdufu, Xueshuantong effective rate was 68.0% (17/25), markedly effective rate was 60.0% (15/25) .Statistical analysis, application of corticosteroids plus thrombus and or The treatment effect of Defu in patients with moderate or severe moderate or severe hearing loss was significantly better than that of Xueshuantong alone (P <0.05) .The rate of vertigo in patients with deafness [88.2% (15/17)] was significantly higher than that in patients with severe flatness Type [26.7% (12/45)], and the curative effect was poor.Conclusion Severe and flat type of prognosis is better, and the combined treatment of high-dose corticosteroid and tolidine is better; Full-deaf type often accompanied by dizziness, the prognosis is poor.