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目的探讨MRI-DWI在早期大鼠肝泡球蚴病模型中的应用价值。方法对接种9w并经超声筛查确认接种成功的40只SD大鼠进行MRI-DWI检查,记录病灶在MRI-T1、T2以及DWI图像上的特点,并与病理结果进行对照。结果早期大鼠肝泡状棘球蚴在T1WI图像上表现为单个或多个类圆形低信号,T2及DWI图像上均表现为单个或多个类圆形高信号,DWI成像中病灶周边可见稍低于病灶内部的环形区,类似“月晕”征。病灶边缘区的ADC值较病灶内部及邻近正常肝组织高(P<0.05)。HE染色镜下见单个或多个囊泡样红染结构,正常肝组织交界区富含微血管,伴炎性细胞浸润。结论早期大鼠肝泡球蚴病灶周边“月晕区”可作为DWI诊断该病较特异的依据,该区域的ADC值高于病灶内部及正常肝实质,经病理证实该区域为富含微血管的区域。
Objective To investigate the value of MRI-DWI in early rat model of alveolar echinococcosis. Methods Forty Sprague-Dawley rats were inoculated on 9 weeks and screened by ultrasound. MRI-DWI was performed on MRI-DWI images. MRI-T1, T2 and DWI images were recorded and compared with pathological findings. Results Echinococcus hepatis showed single or multiple circular low signals on T1WI images and single or multiple circular hyperintensities on T2 and DWI images. The peripheral lesions were visible in DWI images Slightly below the ring within the lesion area, similar to the “Moon halo” sign. The ADC value in the edge of the lesion was higher than that in the lesion and adjacent normal liver (P <0.05). Hematoxylin-eosin staining showed single or multiple vesicle-like red dye structures. The junctional area of normal liver tissue was rich in microvessels with infiltration of inflammatory cells. Conclusion Early perihepatic metacercariae lesions around the “moon halo zone ” can be used as a more specific basis for the diagnosis of DWI in this area, the ADC value higher than the internal lesion and normal liver parenchyma, pathologically confirmed that the area is rich Microvascular area.