目的探讨肺毛霉病的临床表现、诊断和治疗方法。方法本组２例采用纤维支气管镜、开胸探查和痰检查，经病理或真菌培养确诊。结果随着广谱抗生素、抗肿瘤药物、皮质激素和器官移植的广泛应用，发病率有增高趋势。病死率极高，国外报道为８０％，局限于肺部者为６５％，播散型高达９６％。国内报道的１０余例仅１例存活，且多为尸检后明确诊断。本组２例确诊后，其中例１两次行肺叶切除术并于手术前后采用氟康唑治疗，例２单用氟康唑治疗，均痊愈出院。结论对临床可疑病例应及时确诊，有手术适应证者应积极手术切除。氟康唑对肺毛霉病有效 Objective To investigate the clinical manifestations, diagnosis and treatment of pulmonary mucormycosis. Methods The group of 2 cases using fiberoptic bronchoscopy, chest exploration and sputum examination, confirmed by pathology or fungal culture. The results With the widespread use of broad-spectrum antibiotics, anti-cancer drugs, corticosteroids and organ transplantation, the incidence increased. The case fatality rate is extremely high, 80% reported in foreign countries, 65% confined to the lungs, disseminated up to 96%. More than 10 cases reported in China only 1 case survived, and more for post-mortem diagnosis. Two patients were diagnosed in this group, of which case 1 twice lobectomy and preoperative and postoperative use of fluconazole treatment, case 2 single fluconazole treatment, were cured and discharged. Conclusions Clinical suspicious cases should be diagnosed in time, patients with surgical indications should be actively surgically removed. Fluconazole is effective against lung mucormycosis