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血管新生诱导剂与类风湿性关节炎的关系近年来备受关注。本文就血管新生重要诱导剂——血管内皮生长因子的生物学特性,在类风湿性关节炎发病机制、病理改变中的作用,抗血管内皮生长因子治疗等方面作一综述。提出血管内皮生长因子可作为类风湿性关节炎病情活动的指标,抗血管内皮生长因子有望成为类风湿性关节炎治疗的一种新的发展方向。
The relationship between angiogenic inducers and rheumatoid arthritis has drawn much attention in recent years. This review summarizes the biological characteristics of vascular endothelial growth factor, an important angiogenesis inducing agent, in the pathogenesis of rheumatoid arthritis, the role of pathological changes and the treatment of anti-vascular endothelial growth factor. Vascular endothelial growth factor (VEGF) is suggested as an indicator of disease activity in rheumatoid arthritis. Anti-VEGF is expected to become a new development direction of rheumatoid arthritis.