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本文用左旋氧氟沙星（ｌｅｖｏｆｌｏｘａｃｉｎ）治疗伤寒、副伤寒６１例，其中４０例与头孢克肟（ｃｅｆｉｘｉｍｅ）４０例作随机对照。左旋氧氟沙星组痊愈率为９７．５％，临床有效率、细菌阴转率和细菌清除率均为１００％，头孢克肟组的痊愈率、临床有效率，细菌阴转率和细菌清除率均为９０％，两组无显著性差异（Ｐ＞０．０５）。左旋氧氟沙星组平均退热时间为３．４５±１．１４ｄ，短于头孢克肟组的４．９５±１．７１ｄ（Ｐ＜０．０５）。左旋氧氟沙星共治疗伤寒、副伤寒６１例，总临床有效率和细菌清除率均为１００％，药物不良反应发生率为３．２７％，随访３个月未见再燃、复发和带菌者。体外抗菌活性测定显示左旋氧氟沙星对沙门氏菌有强大的抗菌活性。
In this paper levofloxacin (levofloxacin) treatment of typhoid, paratyphoid 61 cases, of which 40 cases and cefixime 40 cases for randomized controlled. The cure rate of levofloxacin group was 97.5%. The clinical effective rate, bacterial negative conversion rate and bacterial clearance rate were 100%. The cure rate, clinical effective rate, bacterial negative conversion rate and bacterial clearance of cefixime group Rates were 90%, no significant difference between the two groups (P> 0.05). The average levofloxacin group antipyretic time was 3.45 ± 1.14d, shorter than the cefixime group 4.95 ± 1.71d (P <0.05). Levofloxacin was treated in 61 cases of typhoid and paratyphoid, the total clinical effective rate and bacterial clearance rate were 100%, the incidence of adverse drug reactions was 3.27%, followed up for 3 months, no reburiation, recurrence and carriers . In vitro antibacterial activity assay showed that levofloxacin had a strong antibacterial activity against Salmonella.