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浅麻醉Ｗｉｓｔａｒ大鼠４９只，用辐射热照尾部作为伤害性刺激，以痛兴奋神经元（ｐａｉｎｅｘｃｉｔａｔｉｏｎｎｅｕｒｏｎｓＰＥＮ）诱发放电频率减少、痛抑制神经元（ｐａｉｎｉｎｈｉｂｉｔｉｏｎｎｅｕｒｏｎｓＰＩＮ）诱发放电频率增加和甩尾反射潜伏期（ｔａｉｌｆｌｉｃｋｌａｔｅｎｃｙＴＦＬ）延长为镇痛效应，观察脑室注射不同剂量吗啡对尾核中ＰＥＮ、ＰＩＮ及ＴＦＬ的同时影响。表明，脑室注射５０μｇ／１０μｌ吗啡，尾核中ＰＥＮ、ＰＩＮ放电呈镇痛效应（Ｐ＜０．０５），ＴＦＬ影响不显著（Ｐ＞０．０５）。注射７０、１００μｇ／１０μｌ吗啡，尾核中ＰＥＮ、ＰＩＮ放电和ＴＦＬ均出现显著镇痛作用，且呈量效关系；吗啡对ＴＦＬ的作用高峰晚于对尾核中ＰＥＮ、ＰＩＮ放电的作用，对ＴＦＬ影响时间长。说明，吗啡对大鼠尾核中ＰＥＮ、ＰＩＮ两者的影响先于其对甩尾反射抑制效应的出现。
In the light anesthetized Wistar rats, 49 rats were used as the nociceptive stimulus with the tail of the radiant heat ray to reduce the frequency of induced discharge of pain excitement neurons (PAE), increase of induced discharge frequency of pain inhibitory neurons PIN and tailflicklatency TTL, Prolong the analgesic effect and observe the simultaneous effect of intraventricular injection of different doses of morphine on PEN, PIN and TFL in caudate nucleus. The results showed that intraventricular injection of morphine 50μg / 10μl, PEN, PIN discharge in the caudate nucleus was analgesic effect (P <0.05), TFL had no significant effect (P> 0.05). There was significant dose-effect relationship between PEN, PIN discharge and TFL in the caudate nucleus, and the effect of morphine on TFL was later than that on PEN and PIN in caudate nucleus. TFL affect a long time. This shows that the effect of morphine on both PEN and PIN in the rat caudate nucleus precedes the appearance of the inhibitory effect on tail-flick reflex.