论文部分内容阅读
哮喘是儿童最常见的异质性慢性疾病,需要长期规律的治疗。哮喘发病机制复杂,多种环境因素同时作用,治疗更是复杂多样。目前,除了避免接触可能诱发哮喘的各种变应原和刺激物外,药物治疗仍然是最基本、最重要的方法。吸入糖皮质激素治疗是控制哮喘的基石,但总体说来单一糖皮质激素吸入治疗,哮喘控制仍然不佳,而加入第2种药物联合治疗可改善症状,达到很好的控制水平。联合治疗包括吸入糖皮质激素联合长效β2受体激动剂、联合白三烯受体拮抗剂以及氨茶碱等治疗。通过比较这些联合治疗用于儿童哮喘的有效性及安全性的研究,可找到最佳治疗途径。
Asthma is the most common heterogeneous chronic disease in children and requires long-term regular therapy. The pathogenesis of asthma is complex, a variety of environmental factors at the same time, the treatment is more complex and diverse. Currently, in addition to avoiding the various allergens and irritants that may trigger asthma, medical treatment remains the most basic and important method. Inhaled glucocorticoid therapy is the cornerstone of asthma control, but in general a single glucocorticoid inhalation therapy, asthma control is still poor, and add the second drug combination therapy can improve symptoms and achieve good control. Combination therapy includes inhaled corticosteroids combined with long-acting beta 2 receptor agonists, combined with leukotriene receptor antagonists and aminophylline and other treatment. By comparing the efficacy and safety of these combination therapies for childhood asthma studies, one can find the best treatment.