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目的用文献计量学的方法对防耐药突变浓度(MPC)理论的研究进展进行分析,为防止细菌耐药研究提供参考。方法检索从1999年至2015年12月PubMed、EMbase、Science Citation Index、中国知网以及万方数据库中MPC的相关文献。用EndnoteX 7进行分类整理,对其发表年份、作者、研究机构、发表期刊、被引频次,研究内容等进行计量分析。结果共纳入文献442篇,其中英文文献266篇,中文文献176篇。发文量最多的年份是2010年,发文量最多的期刊为Antimicrob Agents Chemother。大多数文献仍主要关注于体外研究和动物实验,主要研究是基于MPC的药代动力学/药效学参数测定,但近些年建立的动物体内模型和模拟人体的体外模型在不断增多,研究的内容也倾向于临床应用。结论随着时间的推移,MPC的研究逐渐加深,对临床发挥的作用也日益增加。
OBJECTIVE: To analyze the progress of research on the theory of drug-resistant mutant (MPC) by means of bibliometrics, and provide references for the prevention of bacterial resistance. Methods The literature about MPC in PubMed, EMbase, Science Citation Index, CNKI and Wanfang database from 1999 to December 2015 was searched. EndnoteX 7 for sorting, the publication of the year, the author, research institutes, journals, citation frequency, the content of the study were measured. Results A total of 442 articles were included, of which 266 were English and 176 were Chinese. The largest volume of documents published in 2010, published the largest volume of papers Antimicrob Agents Chemother. Most of the literature is still focused on in vitro studies and animal experiments. The main research is based on the MPC pharmacokinetic / pharmacodynamic parameters, but in vitro models of in vivo and in vitro models established in recent years are on the rise. Studies The content also tends to clinical application. Conclusion With the passage of time, the research of MPC has been gradually deepened and the effect on clinical development has also been increasing.