越来越多的研究表明急性心肌梗死（ＡＭＩ）时，有两种心肌死亡形式：凋亡和坏死。并且在急性心肌缺血６ ｈ 内细胞凋亡是心肌细胞死亡的主要形式，而心肌细胞坏死到１ ｄ～２ ｄ 时才达高峰。进一步提示临床上争取早期恢复心肌再灌流，抑制心肌细胞凋亡，可减小梗死面积。细胞凋亡的调控机制是非常复杂的，涉及多种基因、第二信使因子、细胞内酶活性等。本文作者着重介绍ＡＭＩ时心肌细胞凋亡的研究现状及其调控机制的研究进展 An increasing number of studies have shown that during acute myocardial infarction (AMI), there are two forms of myocardial death: apoptosis and necrosis. And within 6 h of acute myocardial ischemia, apoptosis was the main form of cardiomyocyte death, but the myocardial necrosis reached the peak at 1 d ~ 2 d. Further prompt clinically for early recovery of myocardial reperfusion, inhibition of myocardial cell apoptosis, can reduce the infarct size. The regulatory mechanism of apoptosis is very complex, involving a variety of genes, the second messenger, intracellular enzyme activity. The author of this paper focuses on the research status of cardiomyocyte apoptosis during AMI and its regulatory mechanisms