目的探讨血必净联合乌司他丁对重症急性胰腺炎患者血清炎症因子的影响。方法选择2013年4月至2015年8月急性胰腺炎患者70例,随机分为两组,每组35例。对照组患者实施乌司他丁治疗,观察组患者在对照组的基础上联用血必净治疗,比较两组血清炎症因子、内毒素、超敏C-反应蛋白(hs-CRP)。结果两组治疗前血清炎症因子比较差异未见统计学意义(P>0.05);观察组治疗后肿瘤坏死因子-α、白细胞介素-10评分明显低于对照组,而白细胞介素-6、白细胞介素-8评分明显高于对照组,差异有统计学意义(P<0.05);观察组治疗后内毒素、hs-CRP明显低于对照组,差异有统计学意义(P<0.05)。结论采用血必净联合乌司他丁治疗重症急性胰腺炎效果显著,对降低患者内毒素及hs-CRP水平有明显作用,可有效改善患者血清炎症因子水平,临床应用中具有较高的推广价值。 Objective To investigate the effect of Xuebijing combined with ulinastatin on serum inflammatory factors in patients with severe acute pancreatitis. Methods Seventy patients with acute pancreatitis from April 2013 to August 2015 were randomly divided into two groups (n = 35 in each group). Patients in the control group were treated with ulinastatin. Patients in the observation group were treated with Xuebijing in the control group. Serum inflammatory factors, endotoxin, and hs-CRP were compared between the two groups. Results There was no significant difference in serum inflammatory cytokines between the two groups before treatment (P> 0.05). The scores of tumor necrosis factor-α and interleukin-10 in the observation group were significantly lower than those in the control group, while the levels of interleukin-6, Interleukin-8 score was significantly higher than that of the control group, the difference was statistically significant (P <0.05); the endotoxin and hs-CRP in the observation group were significantly lower than those in the control group after treatment (P <0.05). Conclusion The use of Xuebijing combined with ulinastatin in the treatment of severe acute pancreatitis has a significant effect on reducing endotoxin and hs-CRP levels in patients with significant effect, which can effectively improve the level of serum inflammatory cytokines in clinical application has a high promotional value .