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目的：探讨肿瘤患者免疫偏斜状态及化疗时其的纠正作用。方法：采用ＥＬＩＳＡ法测定了肿瘤患者血清ＩＬ－２、ＩＬ－４、ＴＮＦ－α、ＩＦＮ－γ的水平及一线化疗后上述细胞因子的变化。结果：与正常人对照，ＩＦＮ－γ及ＴＮＦ－α呈显著下降，而 ＩＬ－２和ＩＬ－４变化不显著。正常人：ＩＦＮ－γ ２６６±１９３．５ｐｇ／ｍｌ，ＴＮＦ－α ２９１．２±６４．８ｐｇ／ｍｌ，ＩＬ－２ ３４６．２±１９８．２ｐｇ／ｍｌ，ＩＬ－４ １４８．９±４７．８ｐｇ／ｍｌ。带瘤组：ＩＦＮ－γ ４５．８±３１．２ｐｇ／ｍｌ，ＴＮＦ－α ６２．５±１４２ｐｇ／ｍｌ，ＩＬ－２ ５５２．３±７４２．５ｐｇ／ｍｌ，ＩＬ－４２４０．１±２２４．３ｐｇ／ｍｌ。术后组：ＩＦＮ－γ ３６．４±１８．８ｐｇ／ｍｌ，ＴＮＦ－α ３２．７±１５．１ｐｇ／ｍｌ，ＩＬ－２ ２４５．１±１２３ｐｇ／ｍｌ，ＩＬ－４ １２１．６±１０７．５ｐｇ／ｍｌ。化疗后ＩＦＮ－γ和ＴＮＦ－α均有不同程度回升。带瘤组化疗前：ＩＦＮ－γ ３８．４±２９ｐｇ／ｍｌ，ＴＮＦ－α １８．１±１４ｐｇ／ｍｌ；化疗后：ＩＦＮ－γ ６２±５９．４ｐｇ／ｍｌ，ＴＮＦ－α ３５．４±２５．２ｐｇ／ｍｌ。术后组化疗前：ＩＦＮ?
Objective: To investigate the immunodeficiency status of tumor patients and their corrective effects during chemotherapy. Methods: The levels of serum IL-2, IL-4, TNF-α and IFN-γ in patients with cancer were measured by ELISA, and the changes of above cytokines after first-line chemotherapy. Results: Compared with normal controls, the levels of IFN-γ and TNF-α were significantly decreased, while the changes of IL-2 and IL-4 were not significant. Normal: IFN-γ 266 ± 193.5 pg / ml, TNF-α 291.2 ± 64.8 pg / ml, IL-2 346.2 ± 198.2 pg / ml, IL-4 148.9 ± 47.8 pg / Ml. Tumor-bearing groups: IFN-γ 45.8 ± 31.2 pg / ml, TNF-α 62.5 ± 142 pg / ml, IL-2 552.3 ± 742.5 pg / ml, IL-4240.1 ± 224.3 pg / Ml. Postoperative groups: IFN-γ 36.4 ± 18.8 pg / ml, TNF-α 32.7 ± 15.1 pg / ml, IL-2 245.1 ± 123 pg / ml, IL-4 121.6 ± 107. 5pg / ml. After chemotherapy, IFN-γ and TNF-α all rose to different degrees. Tumor group before chemotherapy: IFN-γ 38.4 ± 29pg / ml, TNF-α 18.1 ± 14pg / ml; after chemotherapy: IFN-γ 62 ± 59.4pg / ml, TNF-α 35.4 ± 25 .2 pg / ml. Postoperative chemotherapy: IFN?