With the method of trend analysis of sediment grain size, the sediment transport trend of the fine-grained sediments area in the central South Yellow Sea was studied. The results demonstrated that there is a sedimentation center around the point of 123.4°E, 35.1°N, and the sediments outside the center are transported to it. The patterns of sediment transportation and deposition in the Yellow Sea should be controlled by cyclonic circulation (including the Yellow Sea Cold Water Mass) and cold water gyre. The study also showed that the method of trend analysis of sediment grain size has prospective utilization in the fine-grained sediment deposited area on large-scale continental shelf.