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本实验用高效液相色谱法测定静脉推注安定１０ｍｇ的１０例产妇血浆中安定和儿茶酚胺浓度，并观察宫口扩张情况，经实用药动学程序处理，安定在产妇体内血药浓度分布呈二室模型。为３．１７±１．２ｍｉｎ，为１７７．８±３７．３ｍｉｎ，ｖｄ为２．４４±１．２６１／ｋｇ，ｃｌ为７１．９±２１．１８ｍｌ／ｍｉｎ。安定血药浓度与血浆儿茶酚胺浓度的降低为正相关（ｙ＝３．６９＋９０．３１ｘ，ｒ＝０．８６，Ｐ＜０．０５），而宫口扩张速度与血浆儿茶酚胺浓度为负相关（ｙ＝１３．６３－０．０４ｘ），ｒ＝－０．９４，Ｐ＜（０．０５）．用药组与对照组有显著差异（Ｐ＜００１）．结果表明安定扩张宫颈可能不是直接作用，而是通过降低血浆中儿茶酚胺浓度而显效。
In this study, plasma and diazepam concentrations of 10 maternal plasma were measured by high performance liquid chromatography (HPLC), and the dilation of cervix was observed. After pharmacokinetic procedures were applied, the plasma concentration of diazepam Room model. Was 3.17 ± 1.2 min, was 177.8 ± 37.3 min, vd was 2.44 ± 1.261 / kg, cl was 71.9 ± 21.18 ml / min. The plasma concentration of diazepam was positively correlated with the decrease of plasma catecholamines (y = 3.69 + 90.31x, r = 0.86, P <0.05), while the rate of cervix dilation was negatively correlated with plasma catecholamines (y = 13.63-0.04x), r = -0.94, P <(0.05). The medication group and the control group were significantly different (P <001). The results show that diastolic expansion of the cervix may not be a direct effect, but by reducing plasma catecholamines and markedly effective.