目的　探讨内皮素 1(Endothelia 1,ET 1)和—氧化氮 (nitrcoxide ,NO )在儿童哮喘发病机制中的作用。方法　对 40例支气管哮喘患儿和 40例正常儿童进行了血浆ET 1及血清NO水平检测。结果　哮喘急性期患儿血ET 1和NO明显高于缓解期 (P <0 0 1) ,缓解期ET 1和NO虽有所下降 ,但仍高于对照组(P <0 0 5)。结论　ET 1和NO水平与哮喘病情严重程度成正相关 ,是反映哮喘严重程度的良好指标 Objective To investigate the role of Endothelia 1 (ET 1) and nitric oxide (NO) in the pathogenesis of childhood asthma. Methods 40 cases of children with bronchial asthma and 40 cases of normal children were detected for plasma ET 1 and serum NO levels. Results The levels of ET 1 and NO in children with acute asthma were significantly higher than those in remission (P <0.01). ET 1 and NO in remission were still lower than those in control group (P <0.05). Conclusions ET 1 and NO levels are positively correlated with the severity of asthma and are good indicators of the severity of asthma