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目的 探讨慢性乙型肝炎患者肝组织过渡型CK19阳性表达细胞与肝癌前病变的关系。 方法用LSAB免疫组织化学染色方法观察慢性乙型肝炎患者肝组织CK19的表达,每3个月对患者检查B超和血清甲胎蛋白,随访至1年。 结果 肝组织出现印圆细胞分化为肝细胞的过渡型CK19阳性表达细胞的患者,大多数出现血清甲胎蛋白的明显升高。随访至1年,有1例患者出现小肝癌,1例出现肝实质低回声结节。结论 过渡型CK19阳性表达细胞有可能作为一种新的肝癌前病变的病理学标志。
Objective To investigate the relationship between the transitional type CK19 positive cells and the precancerous lesions in patients with chronic hepatitis B. Methods The expression of CK19 in liver tissue of patients with chronic hepatitis B was observed by LSAB immunohistochemical staining. The B ultrasound and serum alpha-fetoprotein were examined in patients every 3 months and followed up for one year. Results The majority of patients with transitional CK19-positive cells differentiated into hepatocytes in the liver tissue showed a marked increase in serum alpha-fetoprotein. Follow-up to 1 year, 1 case of small hepatocellular carcinoma, 1 case of parenchymal hypoechoic nodules. Conclusion The transitional CK19 positive cells may serve as a new pathological marker of precancerous lesions of hepatocellular carcinoma.