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目的观察实时动态胰岛素泵对1型糖尿病(T1DM)平均血糖及血糖波动控制的有效性。方法将30例T1DM患者随机分为3C组和CSII组,每组15例。3C组接受持续皮下胰岛素输注(CSII)、实时动态血糖监测(RT-CGMS)和Care Link软件治疗;CSII组接受CSII和指尖血糖监测治疗。两组均佩戴CGMS 3 d,比较3 d平均血糖(MBG)、血糖的标准差(SDBG)、日内平均血糖波动幅度(MAGE)和血糖小于3.9 mmol/L的曲线下面积(AUC3.9)变化情况。结果第1天两组MBG、SDBG、MAGE、AUC3.9差异无统计学意义。第2、3天3C组MBG、SDBG、MAGE、AUC3.9显著低于CSII组,差异均有统计学意义(P<0.05)。结论 3C治疗可以更好地降低T1DM平均血糖,减少血糖波动及低血糖发生。
Objective To observe the effect of real-time dynamic insulin pump on the control of mean blood glucose and blood glucose fluctuation in type 1 diabetes mellitus (T1DM). Methods Thirty patients with T1DM were randomly divided into 3 groups and CSII group, 15 cases in each group. Group 3C received continuous subcutaneous insulin infusion (CSII), real-time dynamic glucose monitoring (RT-CGMS) and Care Link software; CSII received CSII and fingertip blood glucose monitoring. CGMS was performed for 3 days in both groups, and the changes in the area under the curve (AUC3.9) of 3-day average blood glucose (MBG), standard deviation of blood glucose (SDBG), mean daily blood glucose fluctuation (MAGE) and blood glucose of less than 3.9 mmol / L Happening. Results On the first day, the differences of MBG, SDBG, MAGE and AUC3.9 between the two groups were not statistically significant. The levels of MBG, SDBG, MAGE and AUC3.9 in 3C group were significantly lower than those in CSII group on the 2nd and 3rd days (P <0.05). Conclusion 3 C treatment can reduce T1DM average blood glucose, reduce blood glucose and hypoglycemia.