目的　观察格拉司琼 (枢星 )预防给药对介入治疗所致恶心、呕吐的疗效及毒性。方法　对 30例接受介入治疗的肝癌患者 ,采用随机自身对照 ,比较枢星和恩丹西酮的疗效和毒性。结果　枢星能有效地预防肝癌介入治疗所致恶心、呕吐。枢星与恩丹西酮的止吐有效率虽无明显差异 ,但应用枢星患者第二天、第三天平均呕吐次数比应用恩丹西酮少 ,两者差异有显著性 ,表明枢星止吐疗效持续时间较恩丹西酮长 ,且枢星毒副反应小。结论　枢星为肝癌介入治疗安全、有效的止吐剂 ,值得临床推广应用。 Objective To observe the efficacy and toxicity of granisetron (Yuanxing) for prevention of nausea and vomiting caused by interventional therapy. METHODS: Thirty patients with liver cancer who underwent interventional therapy were randomized to their own control and compared the efficacy and toxicity of both cyclazone and ondansetron. Results Ascendants can effectively prevent nausea and vomiting caused by interventional treatment of liver cancer. Although there was no significant difference in the antiemetic efficacy between cyclus and ondansetron, the average number of vomiting patients on the second and third days of the application of cyclamen was less than that of ondansetron, indicating a significant difference between the two groups. The duration of antiemetic treatment was longer than ondansetron, and the side effects of the side effects were small. Conclusion As a safe and effective antiemetic agent for interventional treatment of liver cancer, it is worthy of clinical application.