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采用3种方法制备了氨基修饰的介孔二氧化硅纳米粒(NH2-MSN),对其形貌和结构进行表征。选用其中1种具有较大的比表面积(1 227.4 m2/g)和孔容积(0.67 m3/g)、介孔形状规则且孔径均一的NH2-MSN(称为M3)。该制品的平均粒径为(148.1±3.1)nm,?电位为(37.04±0.22)m V。用其与穿心莲内酯照1∶1的质量比投料制备纳米粒,结果载药量及包封率为(41.7±2.3)%和(80.7±4.7)%。建立了二甲苯致小鼠耳肿胀模型,初步评价该载药纳米粒的药效。结果表明,与穿心莲内酯混悬液及市售片剂相比,该载药纳米粒的抗炎作用较优。
Amino-modified mesoporous silica nanoparticles (NH2-MSN) were prepared by three methods to characterize their morphology and structure. One of them, NH2-MSN (referred to as M3) with larger specific surface area (1 227.4 m2 / g) and pore volume (0.67 m3 / g), uniform mesoporous shape and uniform pore diameter was selected. The average particle size of this product was (148.1 ± 3.1) nm and the potential was (37.04 ± 0.22) mV. The results showed that drug loading and encapsulation efficiency were (41.7 ± 2.3)% and (80.7 ± 4.7)%, respectively. Xylene-induced mouse ear swelling model was established to evaluate the efficacy of the drug-loaded nanoparticles. The results show that compared with andrographolide suspensions and commercially available tablets, the drug-loaded nanoparticles have superior anti-inflammatory effects.