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机体是药物发挥作用的场所,但病理状态下用药不仅影响机体对药物的敏感性,也可改变药物在体内的过程,从而影响药物疗效。一、肝胆疾病肝胜是药物转化的重要器官,肝功能降低会改变肝细胞微粒体酶的活性。实验证明,肝癌动物的微粒体酶几乎不能转化巴比妥类及氯丙嗦,这类患者服用巴比妥及氯丙嗪可能呈现强烈的中枢抑制作用,毒性反应也同时增加。肝硬化者氯霉素的肝内灭活减少,血浆浓度增高,服用同等剂量发生造血功能障碍的毒性反应远较正常者为多;肝硬化时血清蛋白合成减少,血中浓度降低,某些碱性药物如奎尼丁、氨苯砜和氨苯喋啶等与其结合减少,在投给常用量时,药
The body is a place where the medicine plays a role, but it does not only affect the sensitivity of the body to the medicine but also change the course of the medicine in the body, thereby affecting the curative effect of the medicine. First, liver and gallbladder disease Liver wins is an important organ for the transformation of drugs, liver function changes will change the liver cell microsomal enzyme activity. Experiments show that liver microsomal enzymes of the animals almost can not convert barbiturates and chloroacetone, such patients taking pentobarbital and chlorpromazine may show a strong central inhibitory effect, toxicity also increased. Chloramphenicol in patients with cirrhosis decreased inactivation of the liver, plasma concentrations increased, taking the same dose of hematopoietic dysfunction caused by toxic reactions far more than normal; decreased serum protein synthesis in cirrhosis, blood concentration decreased, some of the alkali Drugs such as quinidine, dapsone and triamterene with its combination to reduce the cast in the amount used, the drug