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目的探讨高海拔地区大鼠30%Ⅲ度烧伤后肝细胞损伤程度以及复方红景天对其保护作用机制。方法104只Wistar大鼠随机分为实验组、对照组1组各48只,另取8只作为对照2组;实验组大鼠烧伤前灌胃复方红景天4ml,对照1组灌胃等渗盐水4ml,对照2组大鼠不作处理。分别在烧伤后3、6、12、24、48、72h各时相点剖腹抽血检测血清谷丙转氨酶(GPT)、谷草转氨酶(GOT)及总胆红素(BIL)变化,再摘取大鼠肝脏作病理学检查。结果烧伤后3h实验组与对照1组即出现肝脏的器质性损伤,血清GPT、GOT及BIL亦显著高于对照2组;两组于烧伤后48～72h上述指标接近正常,但实验组较对照1组各项指标明显偏低。结论复方红景天对大鼠高原严重烧伤后的肝脏损伤有显著保护作用。
Objective To investigate the degree of hepatic injury after 30% degree burns in rats at high altitude and the protective mechanism of Rhodiola Compound on it. Methods One hundred and forty Wistar rats were randomly divided into experimental group and control group, 48 in each group, and 8 in the control group. Rats in the experimental group were given intragastric administration of Rhodiola 4ml before burn and control group 1 was irrigated with isotonic saline. Saline 4ml, control group 2 rats were not treated. The changes of serum GPT, GOT, and BIL were measured at 3, 6, 12, 24, 48, and 72 hours after burn, respectively. Rat liver for pathological examination. RESULTS: The organic injury of the liver occurred in the experimental group and the control group at 3h after burn, and serum GPT, GOT, and BIL levels were also significantly higher than those of the control group. The above indexes were close to normal at 48 to 72 hours after burn in the experimental group. The control group 1 indicators were significantly lower. Conclusion The compound Rhodiola rosea has significant protective effect on the liver injury after severe burn of high altitude in rats.