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目的探讨黏蛋白抗原(mucin antigen,MUC)4、5AC在卵巢上皮性肿瘤中的表达情况及其临床意义。方法采用免疫组织化学法对30例正常卵巢组织、30例卵巢良性上皮性肿瘤、30例卵巢交界性上皮性肿瘤和46例卵巢恶性上皮性肿瘤组织中MUC4、5AC的表达情况进行检测。结果 MUC4和MUC5AC在卵巢上皮性肿瘤中有不同程度的表达,MUC4在4组的阳性表达率分别为0、10%、40%、82.5%,MUC5AC在4组的阳性表达率分别为0、50%、40%、15%。结论 MUC4蛋白表达上调或MUC5AC蛋白表达下调可能参与了卵巢上皮性肿瘤的发生、发展过程,与肿瘤的浸润转移有关。
Objective To investigate the expression of mucin antigen (MUC) 4,5AC in epithelial ovarian tumors and its clinical significance. Methods The expression of MUC4 and 5AC in 30 cases of normal ovarian tissue, 30 cases of ovarian benign epithelial tumor, 30 cases of ovarian borderline epithelial tumor and 46 cases of ovarian malignant epithelial tumor were detected by immunohistochemical method. Results The positive expression rates of MUC4 and MUC5AC in ovarian epithelial tumors were 0,10%, 40%, 82.5%, respectively. The positive rates of MUC5AC in 4 groups were 0,50 %, 40%, 15%. Conclusion The up-regulation of MUC4 protein or down-regulation of MUC5AC protein may be involved in the occurrence and development of ovarian epithelial tumor, which is related to the invasion and metastasis of tumor.