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目的 :观察速避凝对脑血栓形成患者血浆组织因子途径抑制物 (TFPI)的影响及其临床意义。方法 :用发色底物法和双抗体夹心 EL ISA法检测 40例急性脑血栓形成患者治疗前后的 TFPI水平。 40例随机分为治疗组 2 3例 ,用速避凝、力抗栓、脑复素和血栓通治疗 ;对照组 17例 ,用力抗栓、脑复素和血栓通治疗。结果 :治疗组 TFPI活性治疗前为(94.2 1± 16 .40 ) U/m L,治疗后为 (175 .90± 6 4.0 1) U/m L(P<0 .0 0 1)。 TFPI含量治疗前为 (32 6 .79± 5 0 .79) μg.L- 1 ,治疗后为 (5 78.82± 85 .42 ) μg.L- 1 (P<0 .0 0 1)。对照组 TFPI活性和 TFPI含量治疗前后比较差异均无显著性 (P>0 .0 5 )。结论 :速避凝是一种安全、有效的抗凝药物 ,可增加 TFPI的含量与活性 ,从而有预防和治疗脑血栓形成的效果
OBJECTIVE: To observe the effect and its clinical significance of rapid tissue protection against plasma Tissue factor pathway inhibitor (TFPI) in patients with cerebral thrombosis. Methods: The levels of TFPI in 40 patients with acute cerebral thrombosis before and after treatment were measured by chromogenic substrate method and double antibody sandwich ELISA. 40 cases were randomly divided into treatment group, 23 cases were treated with fast avoidative coagulation, anti-suppository, nhibi and Xueshuantong treatment; control group of 17 cases, the force of antithrombotic, nhibin and Xueshuantong treatment. Results: The TFPI activity in the treatment group was (94.2 1 ± 16. 40) U / m L before treatment and (175. 90 ± 6 4.0 1) U / m L after treatment (P 0 .01). The level of TFPI was (32 6 .79 ± 5 0.79) μg.L-1 before treatment and was (5 78.82 ± 85 .42) μg.L-1 after treatment (P 0 01). There was no significant difference in TFPI activity and TFPI between the control group before and after treatment (P> 0.05). Conclusion: Fast Avoidance of Condensation is a safe and effective anticoagulant, which can increase the content and activity of TFPI to prevent and treat cerebral thrombosis