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目的:研究冠脉康有效部位群中指纹图谱共有峰与处方药材有效部位及药效的相关性,探讨冠脉康有效部位的药效物质基础。方法:以冠脉康制剂中53个色谱峰的校对峰面积为自变量,以各提取物对小鼠断头后张口喘息时间为因变量进行相关分析和回归分析,研究有效成分与药效的相关性。结果:通过对53个色谱峰的皮尔逊相关系数的计算,发现有12个化学成分与冠脉康抗缺血作用密切相关。结论:初步提示有12个化学组分可能是冠脉康抗缺血的药效物质基础,处方中各药材在抗缺血作用中均有贡献。
OBJECTIVE: To study the correlation between the common peaks of the fingerprint in the effective part of coronary artery and the effective parts and efficacy of prescription herbs, and to explore the pharmacodynamic basis of the effective part of coronary artery. Methods: The calibration peak areas of 53 peaks in coronary intervention were used as independent variables. Correlation analysis and regression analysis were conducted between the extracts for the post-decapitation mouth-time wheezing time of mice and the regression analysis of the effective components and pharmacodynamics Correlation. Results: Based on the Pearson correlation coefficients of 53 chromatographic peaks, 12 chemical components were found to be closely related to anti-ischemic effects of coronary arteries. CONCLUSION: It is suggested that 12 chemical components may be the material basis of anti-ischemic effect of Coripontinum, and all the herbs in the prescription contribute to the anti-ischemic effect.