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目的探讨酒精性肝硬化患者血清胰岛素样生长因子(IGF-1)、骨钙素(BGP)水平及骨密度检测的临床意义。方法采用酶联免疫吸附法、放射免疫法及双能X线骨密度仪测定58例男性酒精性肝硬化患者及34例健康对照者的血清IGF-1、BGP水平及腰椎骨密度,并分析相关性。结果酒精性肝硬化组血清IGF-1、BGP水平、腰椎骨密度较对照组明显降低(P<0.01),随肝功能从Child A级到Child C级逐渐恶化,血清IGF-1、BGP水平、骨密度逐渐下降。血清IGF-1与BGP水平、腰椎骨密度呈正相关。结论酒精性肝硬化患者易发生骨代谢异常,IGF-1、BGP在骨形成减少中起着重要作用,因此,监测其水平对早期诊断酒精性肝硬化骨代谢异常具有一定的临床意义。
Objective To investigate the clinical significance of serum insulin-like growth factor (IGF-1), osteocalcin (BGP) and bone mineral density in patients with alcoholic liver cirrhosis. Methods Serum IGF-1, BGP levels and lumbar spine bone mineral density were measured by enzyme-linked immunosorbent assay, radioimmunoassay and dual-energy X-ray absorptiometry in 58 male patients with alcoholic cirrhosis and 34 healthy controls. Sex. Results The levels of serum IGF-1, BGP and lumbar BMD in alcoholic cirrhosis group were significantly lower than those in control group (P <0.01). The levels of serum IGF-1, BGP, Bone density gradually decreased. Serum IGF-1 and BGP levels, lumbar spine bone mineral density was positively correlated. Conclusions Patients with alcoholic liver cirrhosis are prone to have abnormal bone metabolism. IGF-1 and BGP play an important role in the reduction of bone formation. Therefore, monitoring their levels has some clinical significance in the early diagnosis of abnormal bone metabolism of alcoholic liver cirrhosis.