The Mufushan massif, as continental intra-plate magmatites located in the Jiangnan-Xuefengorogenic belt of the South China. The Mufushan massif constitutes the largest Mesozoic intrusive complex, intruded the Mesoproterozoic Lengjiaxi Formation. Multiple geochronometric dating was used to recon-struct their evolution from emplacement to exhumation. The Mufushan granitoids were emplaced at ～150 Ma (U-Pb zircon) as post-orogenic magmatites contributing to Triassic crustal thickening. Onset of regional extension at ～128 Ma (40Ar/39Ar white mica and biotite) manifests a tectonic regime switch. Intense exhuma-tion prior to ～55 Ma was followed by slow denudation and peneplanation for the next 37 Ma (～55–18 Ma). Accelerated cooling since ～18 Ma may have been caused by a far-field effect of the collision between India-Asia Plate or the Pacific-Plate subduction. Through a multi-geochronometric approach, this study provides a new comprehensive model for the cause of the intra-plate magmatism formation in the South China, and also established a reliable geochronological framework of the post-orogenic tectonic evolutions of the Jiangnan-Xuefeng orogenic belt.