论文部分内容阅读
N 乙基顺丁烯二酰亚胺敏感性的融合蛋白 (N ethylmaleimide sensitivefusionprotein ,NSF)是在细胞内膜泡转运中发挥重要作用的一种ATP酶。它在进化上高度保守 ,参与了不同物种、不同细胞类型的分泌过程。NSF的作用需要可溶性的NSF附着蛋白 (SNAP)和SNAP受体(SNARE)的辅助。“SNARE”假说认为 :NSF主要在分泌小泡与靶膜融合时起作用 ,但近年来倾向于认为其在膜融合过程的多个阶段均发挥作用
N ethylmaleimide sensitive fusion protein (NSF) is an ATPase that plays an important role in intracellular membrane transport. It is highly conserved evolutionary, involved in the secretion of different species, different cell types. The role of NSF requires the assistance of soluble NSF attachment protein (SNAP) and SNAP receptor (SNARE). The SNARE hypothesis states that NSF plays a major role in the fusion of secretory vesicles with the target membrane but in recent years it has tended to be thought that it functions at various stages of the membrane fusion process