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作者报告一例严重银屑病患者因间歇服用氨甲喋呤(MTX)引起了危及生命的肺炎。患者女性,40岁,7岁开始患银屑病,近6年来因皮损加重反复住院。于1973年1月开始用MTX治疗,因既往有肾盂肾炎病史,肾功能有轻度损害,故采用小量(2.5毫克,日二次)间歇12小时口服一次,每周一天。当皮损部分消退后减量为2.5毫克,每周一次。至1974年5月共服MTX16个月,总量215毫克。因全身不适,发热、咳嗽、气短再次住院。入院检查肺部听诊正
The authors report that one patient with severe psoriasis caused life-threatening pneumonia by intermittent methotrexate (MTX). Female patients, 40 years old, 7 years old start suffering from psoriasis, repeated hospitalization for the past 6 years due to increased skin lesions. Beginning in January 1973 with MTX treatment, because of previous history of pyelonephritis, renal function with mild damage, so a small amount (2.5 mg, day two) intermittent 12 hours orally once a week. When the lesion subsided after the reduction of 2.5 mg once a week. To May 1974 a total of MTX service 16 months, a total of 215 mg. Due to malaise, fever, cough, shortness of breath again hospitalized. Admission examination lung auscultation positive